Publication
Identification of a candidate PRODH allosteric inhibitor MBTP-15324: modulation of proline metabolite profiles and ECM-associated gene-expression changes in lung cancer cells.
Yuxuan Zhou, Dingyuan Bai, Zhihan Li, Ciqin Li, Chunqiong Li, Mengyao Chen, Cheng Guo, Jun Yan, Yonglong Han, Quanjun Yang
Journal of enzyme inhibition and medicinal chemistryDec 1, 2026PMID 42635425doi:10.1080/14756366.2026.2719719 PMC13508488Journal ArticlepubmedProvenance
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- PubMed
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- Sep 19, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260919-000001
Abstract
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Current proline dehydrogenase (PRODH) inhibitors lack scaffold diversity. Through virtual screening, microscale thermophoresis, and molecular dynamics simulations, we identified MBTP-15324 as a candidate novel PRODH allosteric inhibitor (Kd = 1.45 μM). In PRODH-overexpressing lung cancer cells…
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Candidate 1
- cancerMalignant Lung Neoplasmdictionary0.60
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