Publication
Tumor-educated adipocytes promote muscle wasting via EV-packaged miR-221-3p targeting IRS1 in pancreatic cancer cachexia.
Wanli Liu, Aoyi Xiao, Jingcheng Zhang, Ruizhe Zhu, Liangrui Zhou, Sumei Zhang, Zixin Zhang, Jinyuan Wang, Dingyan Cao, Huanwen Wu, Xudong Liu, Xianlin Han, Wenming Wu
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- PubMed
- Retrieved
- Sep 19, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260919-000001
Abstract
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Pancreatic ductal adenocarcinoma (PDAC) is often burdened by cachexia, a metabolic disorder characterized by extensive and severe adipose tissue wasting and muscle atrophy that shortens life expectancy. While adipose depletion frequently coincides with myopathy, the precise molecular mediators by…
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- cancerMalignant Pancreatic Neoplasmdictionary0.60
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