Publication
Loss of PBRM1 accelerates pancreatic cancer progression by inducing acquisition of mesenchymal phenotype and inflammatory cancer-associated fibroblasts reprogramming.
Jin Li, Risheng Que, Jian Zhang, Ke Ma, Shouliang Guo, Liang Wen, Jianhui Zhao, Wen Chen, Xun Wang, Hao Qin, Danfeng Qian, Jinyan Huang, Yali Xie, Tao Wei, Tingbo Liang
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- PubMed
- Retrieved
- Sep 19, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260919-000001
Abstract
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BACKGROUND: PBRM1 is an important subunit of the SWI/SNF complex, which broadly regulates gene transcription by chromatin remodeling. Genomic alterations of PBRM1 have been found in patients with pancreatic ductal adenocarcinoma (PDAC), but its molecular functions remain unclear. METHODS: Clinical…
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- cancerMalignant Pancreatic Neoplasmdictionary0.60
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