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Combination of lonidamine with devimistat induces synergistic antitumor effects in lung cancer via multifaceted disruption of cellular energy metabolism.

Xinhe Bai, Yongfeng Yang, Yuling Luo, Pei Jing, Xia Hong, Yaqin Zou, Yan Dai, Xuping Yang, Meiling Zhou, Han Xiao, Yilan Huang, Shiwei Guo, Qingze Fan

Oncology reportsOct 1, 2026PMID 42627059doi:10.3892/or.2026.9184 PMC13504670Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 12, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260912-000001
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Disrupting energy metabolic pathways has emerged as a promising strategy for cancer therapy including non‑small cell lung cancer (NSCLC). However, the ultimate anticancer effects have not been satisfactory. This is likely because cellular energy metabolism encompasses multiple processes and…

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