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Discovery of novel Quinazoline-chalcone hybrids as dual VEGFR-2/P-gp inhibitors to reverse cisplatin resistance in cervical Cancer.

Tong Yan, Mutewaer Muhebuli, Mourboul Ablise, Shulipan Mulati, Wutiekuer Wumaier, Yi Nan Wang, Nuerkaiweisaier Yalikun, Wei Yi Zhang, Zheng Yang

Bioorganic chemistryOct 5, 2026PMID 42623911doi:10.1016/j.bioorg.2026.110411 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 17, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260917-000001
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To address the clinical challenge of cisplatin resistance in cervical cancer, a series of 25 novel quinazoline-chalcone derivatives (5a-5w and 10a-10b) was designed and synthesized using a dual-target strategy. Among them, lead compound 5n displayed potent antiproliferative activity against HeLa…

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