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PSMA binding of carbamate-containing peptidomimetics influenced by side chain length and stereocenter configuration in preclinical prostate cancer model.

Áron Roxin, Helen Merkens, Chengcheng Zhang, Nadine Colpo, Zhengxing Zhang, Ruiyan Tan, Kuo-Shyan Lin, François Bénard

Bioorganic & medicinal chemistryNov 1, 2026PMID 42623854doi:10.1016/j.bmc.2026.118779 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 16, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260916-000001
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To explore how core backbone modifications influence prostate-specific membrane antigen (PSMA) targeting, we synthesized a series of novel peptidomimetics replacing the classic urea linkage of established radiotracers with a carbamate functionality. This panel systematically varied side chain…

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