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Preclinical evaluation of PSMA-targeted ultrasound contrast agents in an orthotopic model of prostate cancer in rabbits.

Felipe M Berg, Eric C Abenojar, Pinunta Nittayacharn, Nathan K Hoggard, Sidhartha Tavri, Jing Wang, Felipe Matsunaga, Michaela B Cooley, Dana Wegierak, Xinning Wang, Thomas J Rosol, James P Basilion, Agata A Exner

Bioactive materialsJan 1, 2027PMID 42621251doi:10.1016/j.bioactmat.2026.07.040 PMC13487017Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 10, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260910-000001
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The localization of prostate cancer by ultrasound remains limited by the lack of B-mode conspicuity and the confinement of clinically approved microbubbles (MBs) to the vasculature. This precludes differentiating viable tumor, necrotic tissue, and margin-associated disease. We investigated…

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