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Cotinine enhances androgen receptor stability and promotes androgen-dependent proliferation in prostate cancer cells: An in vitro study.

Riri Hayashi, Yudai Kudo, Yuta Yoshino, Masaki Shiota, Naohiro Fujimoto, Akira Ikari, Satoshi Endo

Archives of biochemistry and biophysicsNov 1, 2026PMID 42617929doi:10.1016/j.abb.2026.110976 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 18, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260918-000001
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Cigarette smoking is associated with a poor prognosis and reduced efficacy of androgen receptor signaling inhibitors (ARSIs) in prostate cancer patients; however, the underlying molecular mechanisms remain largely undefined. This study investigated the impact of cotinine, the stable primary…

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