Publication
Epigenetic priming and locus-specific demethylation enhance cell-death susceptibility in liver cancer.
Wonjin Woo, Seolhee Jeong, Ayoung Hwang, Su Min Kim, Minjeong Cho, So Hee Dho, Jungmin Choi, Lark Kyun Kim
Molecules and cellsOct 1, 2026PMID 42617749doi:10.1016/j.mocell.2026.100391 PMC13571314Journal ArticlepubmedProvenance
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- Oct 1, 2026
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Liver cancer treatment with epigenetic drugs remains challenging because demethylating agents such as 5-azacytidine (5-AZA) induce genome-wide toxicity and may activate oncogenes. We hypothesized that a low, nontoxic dose of 5-AZA could prime liver cancer cells by partially relaxing chromatin at…
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- cancerMalignant Liver Neoplasmdictionary0.60
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