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ACOD1 enhances the ferroptosis resistance of tumor-associated macrophages through the KEAP1/NRF2 axis and promotes triple-negative breast cancer progression.

Jie Yang, Xiyin Li, Xin Qu, Yaxi Du, Ji Wang, Qi Zhao, Zhuoyou Jiang, Ruoxi Qian, Jianyun Nie

Pathology, research and practiceNov 1, 2026PMID 42617477doi:10.1016/j.prp.2026.156652 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 11, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260911-000001
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BACKGROUND: Tumor-associated macrophages (TAMs), as core components of the triple-negative breast cancer (TNBC) tumor microenvironment (TME), can promote tumor progression. Ferroptosis has been shown to be involved in TNBC progression, but its regulatory mechanisms in TNBC TAMs remain incompletely…

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