Publication
A novel peptide encoded by circTLL1 drives osimertinib resistance in lung cancer by modulating the NT5C2/Ras/PI3K axis.
Miao He, Kun-Peng Li, Wan-Xia Yang, Bin-Yuan Ma, Ya-Xin Xv, Ze-Jing Liu, Hong-Wei Gao
Cellular signallingDec 1, 2026PMID 42612716doi:10.1016/j.cellsig.2026.112831 Journal ArticlepubmedProvenance
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- PubMed
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- Sep 17, 2026
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- ING-PUBMED-20260917-000001
Abstract
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BACKGROUND: Acquired resistance to osimertinib, a third-generation EGFR tyrosine kinase inhibitor, remains a major clinical challenge in the treatment of non-small cell lung cancer (NSCLC). Although circular RNAs (circRNAs) have been increasingly implicated in drug resistance, most studies have…
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- cancerMalignant Lung Neoplasmdictionary0.60
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