Publication
Phenotypic discovery of a pyrimidine derivative with dual anti-prostate cancer and cardioprotective potential via ROS modulation.
Yaquan Cao, Yaxi Wu, Yunfei Li, Shuya Li, Bahaa G M Youssif, Jingxia Du, Liying Ma
Bioorganic & medicinal chemistryNov 1, 2026PMID 42612458doi:10.1016/j.bmc.2026.118776 Journal ArticlepubmedProvenance
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- Sep 12, 2026
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- ING-PUBMED-20260912-000001
Abstract
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Cardiotoxicity remains a major limitation of current anticancer therapies, highlighting the need for agents that combine antitumor efficacy with intrinsic cardiac safety. Phenotypic screening of a pyrimidine-based compound library identified compound 9v as a potent anti-prostate cancer candidate…
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Candidate 1
- cancerMalignant Prostate Neoplasmdictionary0.60
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