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Development of thiazole-hydrazone hybrids for targeted therapy of non-small cell lung cancer.

Mehlika Dilek Altıntop, İpek Ertorun, Gülşen Akalın Çiftçi, Ahmet Özdemir

Bioorganic chemistryOct 5, 2026PMID 42612271doi:10.1016/j.bioorg.2026.110369 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 10, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260910-000001
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To identify targeted cytotoxic agents for the treatment of non-small cell lung cancer (NSCLC), novel thiazolyl hydrazones (2a-t) were synthesized and evaluated for their cytotoxicity toward A549 human lung adenocarcinoma and L929 mouse embryonic fibroblast cells. Among these compounds, compound 2b…

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