Publication
Novel Piperlongumine derivatives exert multimodal antitumor effects in prostate cancer via MAPK pathway activation, poly-mechanistic apoptosis induction, and DNMT3A-mediated DNA methylation reduction.
Yu Zhang, Xue Yang, Xuemei Qiu, Zhurui Li, Danping Chen, Chengpeng Li, Chenchen Li, Yue Zhou, Zhenchao Wang
Bioorganic chemistryOct 5, 2026PMID 42612263doi:10.1016/j.bioorg.2026.110408 Journal ArticlepubmedProvenance
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- Sep 16, 2026
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- ING-PUBMED-20260916-000001
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The high mortality rate of prostate cancer remains a major threat to men's health worldwide, highlighting an urgent need for novel therapeutic agents with improved efficacy and safety profiles. In this study, we employed a rational structural modification strategy to synthesize 14 novel…
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- cancerMalignant Prostate Neoplasmdictionary0.60
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