Publication
The Inv(16) Oncogene CBFB::MYH11 is Required for the Survival of Leukemia Cells in the Blood and Spleen, but not the Bone Marrow.
Sipra Panda, Yiqian Wang, Venkatasai Rahul Dogiparthi, Michelle Becker, Arjun Dhir, Calvin Lam, Cecilia Rivas, Lemlem Alemu, Lisa Garrett, Peng Xiao, Samantha A Swenson, Kyle J Hewitt, R Katherine Hyde
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- PubMed
- Retrieved
- Oct 1, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20261001-000001
Abstract
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Inversion of chromosome 16 [inv(16)] generates the fusion gene CBFB::MYH11 (CM) and is one of the most common chromosomal rearrangements in Acute Myeloid Leukemia (AML). Expression of CM is required for leukemia initiation. Patients with inv(16) at diagnosis invariably have the rearrangement at…
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- cancerLeukemiadictionary0.60
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