Publication
Chelerythrine and chelidonine synergistically target the adenosine pathway to improve anti-PD-L1 immunotherapy efficacy in lung cancer.
Jinglin Zhu, Ruifei Huang, Chao Huang, Jiangna Yan, Yuru Zhang, Yue Xiao, Ruijie Yang, Zhenni Liu, Haixia Guan, Wen Zhang, Liang Li, Zhengtao Xiao, Wei Xiao, Chunli Zheng
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- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260908-000003
Abstract
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BACKGROUND: Despite the success of immune checkpoint blockade in advanced cancer, non-redundant immunosuppressive mechanisms within the tumor microenvironment (TME) limit its effectiveness in many patients. Extracellular adenosine (eADO) signaling is a major contributor to immunosuppression, and…
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- cancerMalignant Lung Neoplasmdictionary0.60
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