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Discovery of novel quinazoline-containing ATR inhibitor for treatment of acute myeloid leukemia.

Xiayu Li, Jiayu Zhang, Jiayu Hao, Maosheng Cheng, Zheng Su, Ye Zhong, Yang Liu

Bioorganic chemistryOct 5, 2026PMID 42600468doi:10.1016/j.bioorg.2026.110363 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 12, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260912-000001
Published

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ATR is a core kinase in the DNA damage response pathway, primarily sensing replication pressure and double strand breaks, initiating cell cycle arrest, DNA repair, and apoptosis programs, and maintaining genomic stability. In this work, we validated that intervention in ATR function might regulate…

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