Publication
Targeting the SELP/PSGL1 axis reprograms M2 macrophages and enhances anti-PD-1 efficacy in gastric cancer.
Yue Wu, Xiaobo Peng, Tong Yin, Xiaoxiao Wu, Jingyu Liu, Yulin Xing, Xian Liu, Shuhui Tang, Xiaoxiao Li, Xianbao Zhan
OncogeneOct 1, 2026PMID 42587106doi:10.1038/s41388-026-03942-2 Journal ArticlepubmedProvenance
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- PubMed
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- Oct 1, 2026
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- ING-PUBMED-20261001-000001
Abstract
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Immune evasion and an immunosuppressive tumor microenvironment contribute to the poor prognosis of gastric cancer (GC), but the mechanisms governing tumor-associated macrophage (TAM) polarization remain unclear. Here we identify P-selectin (SELP) as a key driver of GC progression and immune…
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- cancerMalignant Gastric Neoplasmdictionary0.60
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