Publication
Design, synthesis, and evaluation of novel 5-aminolevulinic acid and 3-hydroxypyridinone conjugates for enhanced photodynamic therapy in triple-negative breast cancer.
Jinhui Ren, Jingqi Zhang, Yan Liu, Yikai Shen, Keren Wang, Changjun Zhang, Yuanyuan Xie
Bioorganic & medicinal chemistry lettersDec 1, 2026PMID 42586492doi:10.1016/j.bmcl.2026.130759 Journal ArticlepubmedProvenance
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- PubMed
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- Sep 11, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260911-000001
Abstract
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Triple-negative breast cancer (TNBC) is a highly aggressive malignancy lacking effective targeted therapies. While 5-Aminolevulinic acid (5-ALA) is an FDA-approved prodrug for photodynamic therapy (PDT), its clinical efficacy against TNBC is severely restricted by poor lipophilicity and the rapid…
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- cancerMalignant Breast Neoplasmdictionary0.60
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