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Risk factors for second primary esophageal cancer after head and neck squamous cell carcinoma: a systematic review and meta-analysis.

T De Bock, A D I Maan, R H A Verhoeven, S Van Roy, O Lenssen, D De Cock, A D Koch, M T Brands

ESMO gastrointestinal oncologySep 1, 2026PMID 42582861doi:10.1016/j.esmogo.2026.100351 PMC13459574Journal ArticleReviewpubmedProvenance
Source
PubMed
Retrieved
Sep 15, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260915-000001
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BACKGROUND: Patients with head and neck squamous cell carcinoma (HNSCC) are at an elevated risk of developing second primary tumors. Esophageal second primary tumors (ESPTs) represent a significant clinical challenge due to their frequent late detection and associated poor prognosis. This…

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