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Complementary intra- and extracellular AGR2 activities support epithelial ovarian cancer cell aggressiveness.

Marianne Guilbard, Saïd Taouji, Marc Aubry, Jacques Robert, Raphael Pineau, Valérie Velasco, Romane Florent, Louis-Bastien Weiswald, Cecile Hartog, Coriolan Lebreton, Alix Coulon, Sabrina Croce, Guillaume Babin, Cédric Chaveroux, Stéphanie Beq, Eric Chevet, Delphine Fessart, Frédéric Delom

OncogeneOct 1, 2026PMID 42575981doi:10.1038/s41388-026-03938-y PMC13600914Journal ArticlepubmedProvenance
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PubMed
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Oct 1, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20261001-000001
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Anterior Gradient 2 (AGR2) is an endoplasmic reticulum (ER)-resident protein that belongs to the protein disulphide isomerase (PDI) family, and whose expression and secretion are induced by stress. Extracellular (secreted) AGR2 has been proposed as a marker of ER stress-related proteostasis…

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