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Pathological lymph node response after immunotherapy-based total neoadjuvant therapy supports local excision for organ preservation in locally advanced rectal cancer: a propensity-score weighted analysis.

Shujuan Zhou, Maoguang Ma, Siyuan Chen, Ting Zou, Yaqi Wang, Lijun Shen, Yan Wang, Fan Xia, Juefeng Wan, Zhen Zhang

Clinical and translational radiation oncologySep 1, 2026PMID 42569463doi:10.1016/j.ctro.2026.101244 PMC13450522Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 9, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260909-000004
Published

Abstract

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BACKGROUND: The immunotherapy-based total neoadjuvant therapy (iTNT) has improved response rates in locally advanced rectal cancer (LARC); however, a majority of patients do not achieve clinical complete response (cCR) and still require total mesorectal excision. High rates of ypT0-1 and…

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Registered trialsNCT04518280

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