Publication
Midkine-activated TRPA1+ cancer-associated fibroblasts promote immunotherapy resistance in gastric cancer through a WNT5A-mediated treg circuit.
Hualong Zheng, Xiaoqian Ye, Linyong Zheng, Xiaobo Huang, Haidan Yan, Zhilong Lin, Qing Zhong, Ruhong Tu, Zhiquan Zhang, Youxin Gao, Qiang Huang, Yifan Li, Yi Li, Xinpeng Yang, Chenyang Jiang, Xiaojing Guo, Maosen Wang, Chaohui Zheng, Ping Li, Jiabin Wang, Jianxian Lin, Changming Huang, Qiyue Chen, Jianwei Xie
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- PubMed
- Retrieved
- Oct 1, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20261001-000001
Abstract
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Gastric cancer (GC) derives limited benefit from immune checkpoint blockade (ICB), in part due to stromal-mediated immune suppression. To investigate the underlying mechanisms, we performed single-cell RNA sequencing on 14 GC specimens from patients treated with neoadjuvant ICB. We identified a…
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- cancerMalignant Gastric Neoplasmdictionary0.60
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