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A Phase 1 Trial of Duvelisib and Oral Azacitidine in Relapsed/Refractory T-Cell Lymphoma.

Hayder Saeed, Melanie Mediavilla Varela, Eva Sahakian, Mahrukh Naqvi, Qianxing Mo, Ling Zhang, Rikesh Makanji, Yumeng Zhang, Ning Dong, Leidy Isenalumhe, Sameh Gaballa, Julio Chavez, Bijal Shah, Celeste Bello, Lubomir Sokol, Javier Pinilla-Ibarz

Hematological oncologySep 1, 2026PMID 42545812doi:10.1002/hon.70235 PMC13431344Journal ArticleClinical Trial, Phase IpubmedProvenance
Source
PubMed
Retrieved
Sep 11, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260911-000001
Published

Abstract

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Mature T-cell lymphomas (TCL) are aggressive malignancies with limited effective therapies. Duvelisib (DUV), a dual inhibitor of PI3K-δ and PI3K-γ, has shown promising activity in TCL. Azacitidine (AZA), a hypomethylating agent, has demonstrated efficacy in TCL and may enhance the activity of PI3K…

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Registered trialsNCT05065866

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