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Neferine-Targeted Inhibition of TrxR1 Triggers Apoptosis Through Disrupting Redox Homeostasis in Pancreatic Cancer Cells.

Xiaoqing Yuan, Si Jiang, Guanqing Zhang, Yue Wang, Qiqiang Xie, Desheng Li, Tao Lu, Huan Liu, Xin Li, Jiayu Zhang, Maolei Xu, Ling Zhou

Molecular carcinogenesisOct 1, 2026PMID 42541494doi:10.1002/mc.70157 PMC13576811Journal ArticleResearch Support, Non-U.S. Gov'tpubmedProvenance
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PubMed
Retrieved
Oct 1, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20261001-000001
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Overactivation of thioredoxin reductase 1 (TrxR1) is implicated in tumor development. This study aims to elucidate the efficacy and mechanisms by which neferine (Nef) exerts its anti-tumor effects in pancreatic cancer through targeting TrxR1. The results demonstrate that Nef directly binds to and…

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