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Low baseline cGAS expression is associated with longer progression-free survival in patients with pleural mesothelioma.

Antoine Torchiat, Karina Silina, Arya Ashok Nair, Laura Viktoria Heeb, Isabelle Opitz, Anurag Gupta, Alessandra Curioni-Fontecedro

Lung cancer (Amsterdam, Netherlands)Sep 1, 2026PMID 42537529doi:10.1016/j.lungcan.2026.109553 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
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INTRODUCTION: The cyclic GMP-AMP synthase (cGAS)/STING pathway, a central DNA-sensing mechanism, is known to activate anti-tumor immune response but may also promote tumor progression when chronically activated. Given the role of asbestos-induced chronic inflammation in pleural mesothelioma (PM),…

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