Publication
LOX-1 mediated lipid peroxidation leads to dysfunction of tumor infiltrating CD8+ T cells in ovarian cancer.
Ting Wang, Lina Yan, Xi Huang, Lingfei Zhou, Yepeng Mao, Shuna Liu, Xin Fu, Jinghang Li, Ziqi Tao, Zhijie Liu, Yuelu Zhang, TingTing Song, Yuexinzi Jin, Fang Wang
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- PubMed
- Retrieved
- Oct 1, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20261001-000001
Abstract
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Abnormal lipid accumulation in the tumor microenvironment (TME) promotes lipid peroxidation in tumor-infiltrating CD8+T cells (CD8+TILs), driving their dysfunction and impairing antitumor immunity in ovarian cancer (OC). To elucidate the underlying immunosuppressive mechanisms, we integrated…
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- cancerMalignant Ovarian Neoplasmdictionary0.60
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