Publication
Single-cell and spatial transcriptomics uncover a THBS2⁺ CAF-KRT17⁺ malignant cell axis drives progression and immunotherapy resistance in pancreatic cancer.
Rui Ma, Yao Xiao, Weixiong Zhu, Haofei Chen, Yeqian Feng, Yusheng Cheng, Junhong Guan
Translational oncologyOct 1, 2026PMID 42520475doi:10.1016/j.tranon.2026.102939 PMC13446304Journal ArticlepubmedProvenance
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- Oct 1, 2026
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Abstract
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BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) features a fibrotic stroma dominated by cancer-associated fibroblasts (CAFs), yet the functional heterogeneity of CAFs and their crosstalk with malignant cells in metastasis and immune evasion remain unclear. METHODS: We performed an integrated…
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- cancerMalignant Pancreatic Neoplasmdictionary0.60
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