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Five-Year Outcomes of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy for Locally Advanced Rectal Cancer: Updated Results of the STELLAR Trial.

Yuan Tang, Hai-Tao Zhou, Tong-Zhen Xu, Ning Li, Li-Ming Jiang, Jun Jiang, Ning-Ning Lu, Shuai Li, Si-Lin Chen, Hui-Ying Ma, Yong Cai, Yong-Heng Li, Yuan Zhu, Ming-Yuan He, Xin Wang, Ke Liu, Hong-Yan Zhang, Jun Wang, Ting Zhao, Gao-Feng Li, Jia-Lin Yang, Kuan Zhang, Wen-Ling Wang, Wei-Wei Xiao, Yihebali Chi, Lin Yang, Ai-Ping Zhou, Shuang-Mei Zou, Hui Fang, Shu-Lian Wang, Hai-Zeng Zhang, Xi-Shan Wang, Li-Chun Wei, Shi-Xin Liu, Yuan-Hong Gao, Ye-Xiong Li, Chen Hu, Jing Jin

Journal of clinical oncology : official journal of the American Society of Clinical OncologySep 1, 2026PMID 42507974doi:10.1200/JCO-25-02387 Journal ArticleRandomized Controlled TrialComparative StudypubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260908-000003
Published

Abstract

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This updated analysis of the STELLAR trial reports 5-year outcomes comparing short-course radiotherapy followed by chemotherapy (SCRT-based total neoadjuvant therapy [TNT]) with standard long-course chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC). Patients with distal…

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Registered trialsNCT02533271

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