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Developing a Histology-Based Artificial Intelligence Biomarker to Predict Adjuvant Chemotherapy Benefit in Pancreatic Cancer.

Audrey Beaufils, Julien De Martino, Xiaofeng Jiang, Théau Blanchard, Nicolas Fraunhoffer, Diana Mendes, Camille Pignolet, Taib Bourega, Asier Rabasco Meneghetti, Srividhya Sainath, Miguel Albuquerque, Nathalie Colnot, Matthieu Tihy, Anthony Turpin, Meher Ben Abdelghani, Alice Wei, Emmanuel Mitry, Thierry Lecomte, James Biagi, Pascal Artru, Ludovic Evesque, Aurélien Lambert, Daniel J Renouf, Marjorie Mauduit, Nelson J Dusetti, Pascal Hammel, Thierry Conroy, Jean-Baptiste Bachet, Louis de Mestier, Vinciane Rebours, Jérôme Cros, Jakob Nikolas Kather, Rémy Nicolle

Journal of clinical oncology : official journal of the American Society of Clinical OncologySep 10, 2026PMID 42507965doi:10.1200/JCO-26-00327 PMC13557473Journal ArticleMulticenter StudypubmedProvenance
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PubMed
Retrieved
Sep 14, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260914-000001
Published

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PURPOSE: The choice of adjuvant chemotherapy in pancreatic ductal adenocarcinoma (PDAC) is mainly guided by patients' general condition. We hypothesized that tumor morphology may predict differential treatment benefit and tested whether deep learning applied to histology images could derive a…

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