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The bone metastatic niche enhances GJA1-20k expression and mitochondrial remodeling in metastatic prostate cancer cells.

Sarah Fournier, Nicolas Delannoye, Isabelle Courtin, Thomas Harnois, Anne Cantereau, Jonathan Clarhaut, Clarisse Vandebrouck, Laurent Cronier, Arnaud Monvoisin

Biochemical and biophysical research communicationsSep 17, 2026PMID 42497839doi:10.1016/j.bbrc.2026.154336 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 18, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260918-000001
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Bone metastases are a major cause of morbidity in advanced prostate cancer (PCa), where tumor cells adapt to a hypoxic and osteoblast-rich microenvironment. Here, we investigated how endosteal niche conditions regulate GJA1-20k expression and mitochondrial dynamics in metastatic PCa cells. We…

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