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AAML1831: A Phase III Trial Comparing Standard Induction Therapy With CPX-351 in De Novo Pediatric AML: A Report From the Children's Oncology Group.

Jessica A Pollard, Todd A Alonzo, Robert B Gerbing, Matthew Kutny, Betsy Hirsch, Gordana Raca, Kasey Leger, Jennifer Wilkes, Reena Pabari, Aman Wadhwa, Zachary Graff, Samir Kahwash, Karen Chisholm, Joseph Chewning, John Horan, Richard Aplenc, Andrew Place, Sarah K Tasian, Katherine Tarlock, Sarah Menig, Olga Militano, Bonnie Ky, Chad Hudson, Michael R Loken, Andrew Menssen, Lisa Eidenschink Brodersen, Soheil Meshinchi, Edward Anders Kolb, Todd M Cooper

Journal of clinical oncology : official journal of the American Society of Clinical OncologySep 20, 2026PMID 42497367doi:10.1200/JCO-25-02979 Journal ArticleClinical Trial, Phase IIIRandomized Controlled TrialComparative StudyMulticenter StudypubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
Published

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PURPOSE: The Children's Oncology Group phase III clinical trial AAML1831 (ClinicalTrials.gov identifier: NCT04293562) evaluated liposomal daunorubicin and cytarabine (CPX-351) versus standard daunorubicin/cytarabine (DA) induction therapy in children and young adults with newly diagnosed AML. We…

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Registered trialsNCT04293562

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