Publication
Scaffold hopping-directed design and discovery of N1-substituted aminopyrimidine-indole derivatives as FAK inhibitors with anti-pancreatic cancer activity.
Libo Cai, Gang Xu, Shaohua Gou
Bioorganic & medicinal chemistryOct 1, 2026PMID 42492381doi:10.1016/j.bmc.2026.118753 Journal ArticlepubmedProvenance
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- Oct 1, 2026
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- ING-PUBMED-20261001-000001
Abstract
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Pancreatic cancer, characterized by its highly aggressive malignancy and suboptimal clinical outcomes, remains a formidable global health challenge. Focal adhesion kinase (FAK) functions as a pivotal modulator of diverse cellular pathways, representing a well-established therapeutic target. In this…
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- cancerMalignant Pancreatic Neoplasmdictionary0.60
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