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Noninvasive Detection of Bladder Cancer via Urinary DNA Mutation and Methylation Profiling Using Modified Real-Time Quantitative PCR.

Di Jin, Hailong Wang, Chen Jiang, Fengwu Zhang, Xinchang Wang, Miaojun Zhu, Hongfei Wu, Qing Cong, Jie Han, Zirui Zhu, Jingdong Xue, Lei Qian, Ming Cao, Lianhua Zhang, Wei Xue, Yiran Huang, Ruoying Tan, Ruiyun Zhang, Haige Chen

The Journal of molecular diagnostics : JMDOct 1, 2026PMID 42480851doi:10.1016/j.jmoldx.2026.07.001 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Oct 1, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20261001-000001
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Cystoscopy is the gold standard for bladder cancer (BC) diagnosis and surveillance but experiences invasiveness and patient discomfort. Existing urine-based assays with single-gene mutation or methylation biomarkers exhibit insufficient diagnostic efficacy, necessitating a reliable noninvasive…

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