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Splicing-mediated control of hnRNPD isoform switching by SRSF2 drives PD-L1-dependent immune evasion in gallbladder cancer.

Cheng Zhao, Lin Jiang, Ming-Yang Wang, Qiu-Yi Tang, Jing-Wei Zhao, Zi-Yi Yang, Jun Gu, Xiao-Ling Song, Ping Dong, Li-Jia Pan, Yi-Jun Shu, Wei Gong

OncogeneSep 1, 2026PMID 42477458doi:10.1038/s41388-026-03898-3 PMC13481249Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
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Gallbladder cancer (GBC), a lethal malignancy of the biliary tract, is associated with a poor clinical prognosis. Although chemo-immunotherapy combinations demonstrate preliminary efficacy, the molecular determinants of treatment response remain elusive. Emerging evidence implicates aberrant…

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