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Incidence and clinical impact of absolute lymphocyte count-only progression in chronic lymphocytic leukemia.

Xiancheng Wu, Mazyar Shadman, Jenna Voutsinas, Daniel S Hippe, Timothy W Randolph, Chaitra S Ujjani, Christine Crider, Sara Keshmiri, Stephen D Smith, Ryan C Lynch, Mengyang Di, Jennifer J Huang, Paul S Martin, Brian G Till, Ajay K Gopal

Blood advancesSep 22, 2026PMID 42466974doi:10.1182/bloodadvances.2026020680 PMC13594711Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260930-000001
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An increase in the absolute lymphocyte count (ALC) is a component of progressive disease (PD) in chronic lymphocytic leukemia (CLL) and contributes to progression-free survival in phase 3 trials. Prior studies with chemoimmunotherapy demonstrated that PD by ALC alone (ALC PD) conferred better…

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