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Environmental benzophenone exposure promotes liver cancer cell proliferation via the IRE1α-XBP1s pathway.

Rong Wang, Jing Yang, Kailun Wang, Liwei Chen, Hongqing Zhou, Xia Sheng, Mei Zhao, Mingsheng Liu, Yanxia Hu

Food and chemical toxicology : an international journal published for the British Industrial Biological Research AssociationOct 1, 2026PMID 42442597doi:10.1016/j.fct.2026.116277 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Oct 1, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20261001-000001
Published

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Humans are widely exposed to benzophenones, ultraviolet absorbers in sunscreens that accumulate in the liver. This study investigated the impact of chronic benzophenone exposure on hepatocellular carcinoma (HCC). We established a long-term culture model treating HepG2, Huh7 and normal hepatocyte…

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