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Targeted intracellular glucose oxidase nanotherapy enables single-dose treatment of prostate cancer.

Saeed Manouchehri, Niloofar Fatemipayam, Akansha Singh, Abanoub Hanna, Amir Erfani, Sunil More, Ashish Ranjan, Joshua D Ramsey

International journal of pharmaceuticsSep 5, 2026PMID 42442513doi:10.1016/j.ijpharm.2026.127194 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260908-000003
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Glucose oxidase (GOX) is an enzyme that generates hydrogen peroxide (H2O2) and is considered a potential cancer therapy. However, effective delivery of GOX to tumor cells remains challenging, and parenteral administration leads to systemic toxicity and immunogenicity. In this study, GOX is…

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