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Spatial transcriptome profiling links SERPINA3 to nerve-associated immunosuppression in pancreatic cancer.

Bihan Liu, Yuankang Yang, Yuxi Zhang, Chenglin Xin, Tianzhen Zhang, Lehan Pan, Zhongtao Zhang, Yingchi Yang, Wei Guo, Dan Tian

Biochemical and biophysical research communicationsSep 10, 2026PMID 42442087doi:10.1016/j.bbrc.2026.154222 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 14, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260914-000001
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Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy in which perineural invasion (PNI) represents a key indicator of poor prognosis; however, the underlying mechanisms of neuro-immune crosstalk remain incompletely understood. To address this, we integrated spatial transcriptomics,…

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