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A novel radionuclide probe targeting FN-EDB: a new strategy for radioactive iodine-refractory differentiated thyroid cancer.

Xue Jiang, Qian Liu, Yuxiao Xia, Lina Liu, Dongkun Xu

Bioorganic chemistrySep 15, 2026PMID 42424919doi:10.1016/j.bioorg.2026.110189 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 26, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260926-000001
Published

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OBJECTIVE: To synthesize a novel 161Tb-DOTA-EDB theranostic probe targeting fibronectin extra-domain B (FN-EDB), and further validate its potential for preclinical translational applications. METHOD: After synthesis of EDB antibody, p-SCN-Bn-DOTA was used for site-specific modification to construct…

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