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Mismatch repair deficiency or microsatellite instability in locally advanced rectal cancer patients treated with total neoadjuvant therapy.

Nada Benhima, Alessandro Audisio, Chiara Gallio, Gianluca Ricco, Hélène Meillat, Vaneja Velenik, Maria Carmen Riesco, Javier Suárez Alecha, Gertjan Rasschaert, David Páez López-Bravo, David Tougeron, Carlos Carvalho, Beatrice Borelli, Federico Famiglietti, Carolina De la Pinta, Juan Manuel O'Connor, Mehmet Artaç, Pètra M Braam, Alberto Puccini, Ithai Waldhorn, Alexander Vanden Bulcke, Mauro Loi, Francesca De Felice, Michal Eid, Amélie Deleporte, Chiara Rossini, Paola Montenegro, Michele Fiore, Marc Van Den Eynde, Ali Shamseddine, Karen P Geboes, Marco Messina, Núria Mulet Margalef, Constance Houlzé-Laroye, Iva Kirac, Alessandro Pastorino, Massimiliano Salati, Soňa Argalácsová, Federica Morano, Jaume Capdevila, Ingrid Garajovà, Claire Antoun, Cidália Maria Sousa Pinto, Manfred P Lutz, Richard A Adams, Amélie Chau, Alexander Siebenhuener, Alexandre Dermine, Michele Ghidini, Audrius Dulskas, Demetris Papamichael, Muhammad Ahsan Javed, Erika Ruiz-Garcia, Jiří Tomášek, Angelica Petrillo, Chiara Baratelli, Timon Vandamme, Gaya Spolverato, Felix Bock, Marie Diaz, Luca Giovanni Campana, Daniel Sur, Athanasios Karampeazis, Veronika Patsko, Francesco Puleo, Adda Bounedjar, Francesco Fiorica, Quentin Gilliaux, Ilaria Bernardini, Alfonso De Stefano, Marianne Grønlie Guren, Matas Jakubauskas, Fatma Sert, Maria Gomez Galdon, Ana Veron Sanchez, Ortansa-Irina Vierasu, Irene Assaf, Luigi Moretti, Philippe Martinive, Gabriel Liberale, Jean-Luc Van Laethem, Francesco Sclafani, International Real-World TNT Study Consortium

European journal of cancer (Oxford, England : 1990)Sep 9, 2026PMID 42407299doi:10.1016/j.ejca.2026.116911 Journal ArticleMulticenter StudyObservational StudypubmedProvenance
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PubMed
Retrieved
Sep 19, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260919-000001
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BACKGROUND: Data on the prognostic value of dMMR/MSI-H in locally advancer rectal cancer (LARC) are inconsistent and mostly from patients treated with conventional neoadjuvant therapy. We sought to evaluate oncological outcomes by mismatch repair/microsatellite (MMR/MS) status in LARC patients…

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