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Synthesis and biological evaluation of 6,9-disubstituted purine analogues inducing autophagy-mediated apoptosis and potentiating carboplatin response in high-grade serous ovarian cancer.

Pınar Kul Karadenizli, Deren Demirel Yavuz, Duygu Altıparmak, Gizem Yilmaz Demir, Idil Su Canitez, Meral Tuncbilek, Irem Durmaz Sahin

Bioorganic chemistrySep 15, 2026PMID 42391813doi:10.1016/j.bioorg.2026.110197 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 18, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260918-000001
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High-grade serous ovarian carcinoma (HGSOC) is the most lethal ovarian cancer subtype, characterized by late diagnosis, high recurrence, and resistance to platinum-based chemotherapy and PARP inhibitors. TP53 inactivation and defects in homologous recombination repair, including BRCA1/2 loss,…

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