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VISTA+ Neutrophils Contribute to Platinum Resistance by Suppressing CD8+ T Cells in High-Grade Serous Ovarian Cancer.

Chuying Huo, Xibo Zhao, Dongdong Ye, Shaodan Lin, Dongdong Xu, Suen Wai Pang, Miaochun Xu, Junting Chen, Chunxian Huang, Yunyun Liu, Aoshuang Cheng, Lingjie Yang, Zhongqiu Lin, Lijuan Wang, Bowen Li, Huaiwu Lu

Cancer immunology researchSep 2, 2026PMID 42390478doi:10.1158/2326-6066.CIR-25-1118 PMC13535324Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 10, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260910-000001
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Elevated neutrophil-to-lymphocyte ratio (NLR) has been associated with platinum resistance and poor outcomes in high-grade serous ovarian cancer (HGSOC), but the biological basis of this association remains unclear. We retrospectively analyzed 434 patients with HGSOC treated with platinum-based…

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