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High-Sensitivity ctDNA Analysis Uncovers Relevant Signals Missed by NGS in Pancreatic Cancer.

Krishay Sridalla, Jasmine K Machhi, Dominic J Vitello, Anastasia Chibucos, Madison Cox, Amy Wells, Alex Horowitz, Vishvetha Rengaraju, Claire Shen, Nicole Romero, Isabel Temosihue, Lauren M Janczewski, John Abad, Kevin Dawravoo, David Bentrem, Lawrence J Jennings, Qiang Zhang, Akhil Chawla

Clinical cancer research : an official journal of the American Association for Cancer ResearchSep 15, 2026PMID 42377115doi:10.1158/1078-0432.CCR-26-0609 PMC13405252Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 18, 2026
Layer
normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260918-000001
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PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) carries high mortality despite multimodal therapy, and improved biomarkers are needed to guide perioperative care. This study evaluated the prognostic significance of Kirsten rat sarcoma virus (KRAS)-mutant circulating tumor DNA (ctDNA) detected by…

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