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Heterogeneous SPP1-expressing esophageal cancer cells license immunotherapy resistance by organizing an immunosuppressive niche.

Jiakang Ma, Jianlin Zhu, Yiling Chen, Xiaodong Chu, Jie Zeng, Hongyu Chen, Yuhao Liu, Xiaosheng Lin, Lei Zhang, Jinyuan Yi, Guangping Zhang, Songwang Cai, Yusheng Lin, Lu Wang

Neoplasia (New York, N.Y.)Sep 1, 2026PMID 42349108doi:10.1016/j.neo.2026.101331 PMC13325454Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 11, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260911-000001
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BACKGROUND: Esophageal squamous cell carcinoma (ESCC) remains a major cause of cancer-related mortality worldwide, with immunotherapy resistance representing a critical therapeutic challenge. This resistance is driven by profound tumor heterogeneity that fosters diverse immune evasion mechanisms,…

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