Publication
Discovery of furan-trimethoxyphenyl hybrids as novel colchicine-binding site inhibitors that induce mitotic catastrophe with potent anti-acute myeloid leukemia effect.
Peng Tan, Xuejiao Wei, Longyan Wang, Fei Wang, Huiming Huang, Zhuguo Wang, Xinyu Qiu, Ruoxin Zhang, Yufeng Gao, Wanying Xie, Xiaoxue Wang, Dongjun Fu, Zhongdong Hu
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- PubMed
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260929-000001
Abstract
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Acute myelocytic leukemia (AML) is a common leukemia subtype in adults, necessitating novel, potent treatments. Microtubule-targeting agents (MTAs) are key anti-cancer drugs widely used in clinical practice. A series of novel furan-trimethoxyphenyl hybrids as tubulin polymerization inhibitors were…
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- cancerLeukemiadictionary0.60
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