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Neuropilin-1 mediates nerve growth factor signaling of oral cancer pain.

Maria Fernanda Pessano Fialho, Elisa Damo, Raquel Tonello, Brian L Schmidt, Nigel W Bunnett

PainSep 1, 2026PMID 42289102doi:10.1097/j.pain.0000000000004021 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 14, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260914-000001
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Oral cancer is one of the most painful malignancies, with pain driven primarily by algogenic mediators in the tumor microenvironment, including nerve growth factor (NGF). Although NGF monoclonal antibodies alleviate cancer pain in patients, clinical development was halted because of adverse…

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