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A blood-urine regulatory axis: Tumor-derived factors reprogram urine-derived stem cells via CXCL2/CXCR2/ERK signaling to drive bladder cancer stemness.

Dongkai Sun, Chunhua Han, Dan Li, Peng Li, Xintao Tian, Zhijuan Liang, Yuanbin Chen, Liping Wang, Shuaishuai Li, Lijiang Sun, Ye Liang, Haitao Niu

Cancer lettersSep 28, 2026PMID 42285214doi:10.1016/j.canlet.2026.218675 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
Published

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The malignant progression of bladder cancer is closely linked to the tumor microenvironment, yet the role of urine-derived stem cells (USCs) remains poorly understood. USCs were isolated from healthy individuals and bladder cancer patients, followed by multi-omic and functional characterization.…

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