Publication
A homologous cell membrane-coated peptide-based USP7 degrader enhances degradation efficiency and anti-tumor activity in gastric Cancer.
Cong-Cong Ma, Cheng-Yun Jin, Nin-Jie Guo, Hong-Min Liu, Qian-Ge Yin, Yu-Bing Wang, Yu-Fei Liu, Yu Zhang, Ning Wang, Guo-Liang Lu, Yan Li, Nan-Zhang, Yi-Chao Zheng
- Source
- PubMed
- Retrieved
- Sep 18, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260918-000001
Abstract
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Ubiquitin-specific protease 7 (USP7) is an oncogenic deubiquitinase that promotes tumor cell proliferation and immune evasion, making it a promising therapeutic target. Here, we designed peptide-based proteolysis-targeting chimeras (p-PROTACs) by leveraging Epstein-Barr nuclear antigen 1 (EBNA1), a…
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Candidate 1
- cancerMalignant Gastric Neoplasmdictionary0.60
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