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A Randomized Phase II Study of Subcutaneous Mosunetuzumab in Combination With Polatuzumab Vedotin Compared With Rituximab Plus Polatuzumab Vedotin in Patients With Relapsed or Refractory Large B-Cell Lymphoma.

Julio C Chavez, Mariana Bastos-Oreiro, Catherine Diefenbach, Izidore S Lossos, Nirav Shah, Sarit Assouline, Adam J Olszewski, Seema Naik, Nilanjan Ghosh, Song Pham, Michael C Wei, Connie Batlevi, Iris To, Wahib Ead, Sneha Makadia, Elicia Penuel, Jing Jing, Lihua E Budde

American journal of hematologySep 1, 2026PMID 42283231doi:10.1002/ajh.70403 PMC13428363Journal ArticleClinical Trial, Phase IIRandomized Controlled TrialMulticenter StudyComparative StudypubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260908-000002
Published

Abstract

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Mosunetuzumab plus polatuzumab vedotin has shown promising activity versus rituximab plus polatuzumab vedotin (R-Pola) in patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL; NCT03671018). We present results from the Phase II randomized cohort, evaluating subcutaneous mosunetuzumab…

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Validated 2

Registered trialsNCT03671018NCT05171647

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